Novel Therapeutic Strategy Against Central Baroreflex Failure
نویسندگان
چکیده
منابع مشابه
Novel therapeutic strategy against central baroreflex failure: a bionic baroreflex system.
BACKGROUND Central baroreflex failure in Shy-Drager syndrome and traumatic spinal cord injuries results in severe orthostatic hypotension and often confines the patient to the bed. We proposed a novel therapeutic strategy against central baroreflex failure: implementation of an artificial feedback control system able automatically to regulate sympathetic vasomotor tone, that is, a bionic barore...
متن کامل[Therapeutic strategy against multiple sclerosis].
The pathogenesis of multiple sclerosis (MS) remains to be elucidated and there is no curative therapy against MS, though we have several disease modifying drugs. In this symposium. I introduce several new strategies against development of autoimmune processes and axonal degeneration in MS. Several mechanisms regulate immune system not to attack self components. One of the most potent regulatory...
متن کاملFKBP12.6-mediated stabilization of calcium-release channel (ryanodine receptor) as a novel therapeutic strategy against heart failure.
BACKGROUND The development of heart failure is tightly correlated with a decrease in the stoichiometric ratio for FKBP12.6 binding to the ryanodine receptor (RyR) in the sarcoplasmic reticulum (SR). We report that a new drug, the 1,4-benzothiazepine derivative JTV519, reverses this pathogenic process. JTV519 is known to have a protective effect against Ca2+ overload-induced myocardial injury. ...
متن کاملClodronate as a Therapeutic Strategy against Osteoarthritis
Osteoarthritis (OA), the most prevalent musculoskeletal pathology, is mainly characterized by the progressive degradation of articular cartilage due to an imbalance between anabolic and catabolic processes. Consequently, OA has been associated with defects in the chondrocitic differentiation of progenitor stem cells (PSCs). In addition, SOX9 is the transcription factor responsible for PSCs chon...
متن کاملNovel therapeutic target against Alzheimer
Novel therapeutic targets against which we can develop medications are urgently needed in the field of Alzheimer Disease (AD) research. While immense progress has been made in the description and diagnosis of AD, no effective medication to prevent or treat AD exists. Yet, 47 million individuals suffer from AD worldwide. The cost to care for AD and other dementias is $259 billion dollars/year in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation
سال: 1999
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.100.3.299